The Misfire skillshot is achieved by shooting a Screamer's Charge Shot into an enemy an having them hit an environmental hazard such as spikes or cacti. This is fairly hard to do, as you do not have enough time to switch weapons or aim the Screamer properly after the flare has been fired. However it can be made rather simple if you can get en enemy to stand in front of a hazard then hit him with the flare.
Trivia
- The term "misfire" is used when a weapon fires unintentionally or is used against the wrong target with undesired effects.